Family Proteins in Mammals
نویسندگان
چکیده
DNA damage causes chromosomal instability leading to oncogenesis, apoptosis, and severe failure of cell functions. The DNA repair system includes base excision repair, nucleotide excision repair, mismatch repair, translesion replication, non-homologous end-joining, and recombinational repair. Homologous recombination performs the recombinational repair. The gene is an ortholog of , and the gene product Rad51 protein plays a central role in the homologous recombination. In mammals, 7 genes have been identified: / / / , and . These genes, with the exception of meiosis-specific , are essential for development in mammals. Disruption of the gene leads to cell death, whereas / / / , and genes( paralogs)are not essential for viability of cells, but these gene-deficient cells exhibit a similar defective phenotype. Yeast two-hybrid analysis, co-immunoprecipitation, mutation analysis, and domain mapping of Rad51 and Rad51 paralogs have revealed protein-protein interactions among these gene products. Recent i
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